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Resistant hypertension is defined as seated office BP >140/90 mm Hg in a patient treated with three or more antihypertensive medications at optimal (or maximally tolerated) doses including a diuretic and after excluding pseudoresistance (poor BP measurement technique, white coat effect, nonadherence and suboptimal choices in antihypertensive therapy) ^{104, 105} as well as the substance/drug-induced hypertension and secondary hypertension. ⁷⁹ Resistant hypertension affects around 10% of hypertensive individuals, has a negative impact on well-being ¹⁰⁶ and increases the risk of coronary artery disease, chronic HF, stroke, end-stage renal disease, and all-cause mortality. ¹⁰⁷ Approximately 50% of patients diagnosed with resistant hypertension have pseudoresistance rather than true resistant hypertension. ^{104, 105, 108}

The white-coat effect occurs because a hypertensive patient experiences BP elevation in the clinic, whereas out-of-office BP monitoring reveals BP that is less than 140/90 mm Hg. It has been reported that in white-coat hypertensive patients, BP control by 24-hour ABPM was not different from that of normotensive controls, whereas ambulatory SBP and DBP were significantly lower in the normotensive controls.

For patients with hypertension, the ABPM device is more accurate than the home BP monitoring device in determining BP control. A meta-analysis of 5 trials showed that compared to usual care, ABPM-guided therapy decreased office and home BPs by 8.5/2.0 and 5.8/0.6 mm Hg, respectively. ³⁰ According to the 2013 ACC/AHA hypertension guidelines, the target BP for patients with RH is <130/80 mm Hg. However, in a recent analysis from the same trial, approximately one-third of patients with RH had uncontrolled office BP and a correspondingly higher adjusted hazard ratio of clinical cardiovascular events than in patients without RH, based on office BP and ABPM values. ³⁰

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The installation files for Office Professional Plus 2021 are available on the Office Content Delivery Network (CDN) on the internet instead of on the Volume Licensing Service Center (VLSC). You can install Office Professional Plus 2021 directly from the Office CDN. Or, you can download the installation files from the Office CDN to a location on your local network, such as a shared folder, and install Office Professional Plus 2021 from that location. You can use different methods for different sets of devices in your organization. Whichever method you choose, you use the ODT.

If you want to check that the files are downloading, go to the location you specified for your SourcePath in the configuration.xml file. You should see a folder named Office with a subfolder named Data. There will also be a folder named with the version number of the download. For example, 16.0.14332.20099. Which files you see and the names of the files depend on whether you are downloading the 32-bit or 64-bit version of Office and which languages you are downloading.

Microsoft 365 Business, is a feature-rich cloud-based productivity solution for your enterprise of up to 10 users that includes Mail, OneDrive for Business, Yammer, SharePoint, Skype for Business, Microsoft Teams, Office 365 Groups and more. Microsoft 365 Business includes the Office applications you need to do your most important work, as well as the instant access to the latest versions, whether on-premises or in the cloud. We understand that collaboration across an enterprise can be complex. To make it easier for users to share and work together, Microsoft 365 Business is a set of integrated, cloud-based services that include high-quality Office applications, a shared document server, built-in communications, security, and compliance tools, and built-in mobile device management to keep information secure and collaboration in sync across devices.

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Beginning with this release, Microsoft and Windows have detected a bug in the TIF format library TIFF6U.DLL and Windows has provided a fix to this in this release. For more information, please see the following Microsoft blog post: .

Microsoft and Windows have detected a bug in the TIF format library TIFF6U.DLL and Windows has provided a fix to this in this release. For more information, please see the following Microsoft blog post: .

This article is currently undergoing editing. All testing and reviews are done through the SharePoint Designer User Experience evaluation tool or SharePoint Designer itself. Office doesn’t include any built in evaluation. For more info on the evaluation tool, see this blog entry.

You need to use a Test Account to install your evaluation license or you will need to supply your own license. To install it you will need to use the same account that you installed the tools with. To verify that your users have the tools installed, point them to the following site: Office365 Evaluation . If they click the link they will see a confirmation dialog that the tool has been installed.

To help our customers transition to Remote Desktop Connection (RDC) Preview, we are offering a free trial of RDC Preview for Windows 10. We encourage you to install RDC Preview and try out the new experience. However, the free trial is limited to one (1) desktop session. If you wish to test your RDC configuration in a Production environment, this version of RDC Preview is not intended for use with Office Online ProPlus or an Office 365 subscription.

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• Admin consent
• Improved security due to stateless OAuth 2.0
• Attachments can be shared in their original state, meaning they are not converted from non-image formats
• Version History of documents
• Document Restrictions
• Change Tracking
• Label Changes
• View Properties
• Hide Ribbon
• Faster start up due to enhanced caching
• Faster form recovery
• Better interoperability, Now using the improved APIs for calendar and contacts
• Switched to the new URI format
• Proper rendering of PDFs.
• Added a new icon for new share link
• Respect user active folder.
• Improved Windows 7 compatibility
• General bug fixes

• Windows 10 64 bit or Windows 8.1
• 1 GB RAM
• 2 GB hard drive space
• 16 GB of available hard drive space
• A secondary storage device, such as a CD-R/RW, DVD-RW, USB flash drive, or external hard drive, to store installation files
• DirectX® 9 or DirectX® 10 graphics card or compatible graphics board with 128 MB or more video memory
• Microsoft Windows® 7 or Windows® 8 operating system
• 32- or 64-bit operating system

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